Gastroprotective effects of Taraxacum officinale (Dandelion) extract indomethacin-induced gastric ulcer model

In this study, it was aimed to investigate the gastroprotective and anti-inflammatory effects of extract (TO) obtain from leaves Taraxacum officinale, which is used in treatment many diseases including gastric ulcers traditional medicine, an indomethacin-induced ulcer model. Forty rats, 10 animals each group, were divided into four groups (Control (C), TO + Indomethacin (TO+IND), (IND) Omeprazole (O+IND) groups). Respectively group C given isotonic saline, TO+IND 100 mg/kg extract, IND saline O+IND 5 omeprazole orally. On 11th day a single dose indomethacin administered orally TO+IND, groups. It determined that cyclooxygenase-2 (COX-2), C-reactive protein (CRP) Interleukin-6 (IL-6) levels significantly increased compared K (p<0.001). However, these markers decreased both (respectively p<0.05, p<0.001, p<0.05) (p<0.05, respectively) when with group. No significant changes observed tumor necrosis factor-alpha (TNF-α) levels. Depending on administration indomethacin, found index tissue but as result administrations As result, officinale leaf showed by reducing COX-2, CRP IL-6 ulcerative area formation tissue.